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Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

AMPK antagonizes mammalian target of rapamycin (mTOR) activity, and its downstream effector, p27, inhibits cyclin-dependent kinase 2 (CDK2), thereby blocking the G1/S transition in the cell cycle, halting cell division, and subsequently inhibiting cellular proliferation [57]

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The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving blood flow, and modulation of dopamine and serotonin systems

DG5, n =1) and 5.1% receiving placebo ( n =3) (Table 3, ESM Table 3)