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It is concluded that riboflavin could act as an antioxidant against oxidative stress, especially lipid peroxidation and reperfusion oxidative injury

This attenuates angiotensin II (Ang II)-induced oxidative stress, DNA double-strand breaks, and podocyte damage, which is closely related to the pathogenesis of CKD [81] (Table 2)

N Engl J Med 377:644657 Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS (2019) Dapagliflozin and cardiovascular outcomes in type 2 diabetes

Some patients report anecdotal temperature sensitivity, but no causal link has been proven through clinical trials