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Together with Derek Holdsworth, another gastroenterologist trainee, and Desmond Turner, a biochemist, McIntyre decided to revisit La Barre's hypothesis that the duodenum encouraged the pancreas to produce insulin by releasing incretin

The cells were then stimulated with 100 nM exendin-4, or vehicle, and the plate read for a further 20 minutes

Graphic plots were converted to a percentage defined as % F / F 0

Research is ongoing to understand the full potential of side effects and implications of taking GLP-1 RAs in these particular populations

Reduced Concern About Long-Term Medication Use Microdosing is sometimes discussed as a way to use GLP-1 medications more conservatively