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10.3390/ijms25115587 17 ArnoldS

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Oshimori N, Oristian D, Fuchs E

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Hyperglycemia increases notch activity in vitro and vivo, and consistent activation of notch results in impaired GSIS and blocks maturation of cells, which may be a result of degradation of MAFA due to the blockage of its binding to kat2b