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At one year, the risk of a composite TED-related diagnosis was 0.77% in the GLP-1 group vs

Week 1: 0.6mg (0.2ml) once daily (20 units) Weeks 2: 1.2mg (0.4ml) once daily (40 units) Weeks 3: 1.8mg (0.6ml) once daily (60 units) Week 4: 2.8mg (0.8ml) once daily (80 units) Week 5 onwards: 3mg (1ml) once daily (100 units) (on-going maintenance dose) If patients can't tolerate a higher dose during dose escalation, the increase can be delayed by one more week

For a 220-pound person, that is roughly 11-22 pounds with phentermine versus 35-50 pounds with tirzepatide

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