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These include the following: Older adults - As the body ages, it gets harder to extract nutrients from our food

This suggests it is cleared from the system quite rapidly, which has major implications for study design and dosing frequency

But how long does it take to bounce back once you've started addressing the deficiency

Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision

Elevated IGF-1 levels raise concerns about potential proliferative effects on existing malignancies, making growth hormone therapy problematic for individuals with cancer history or elevated cancer risk