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Malignant Peripheral Nerve Sheath Tumor (MPNST) is a rare and highly aggressive form of soft tissue sarcoma that arises from the Schwann cells or fibroblasts that form the protective sheath around peripheral nerves

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During the resolution of inflammation, SPMs produced by polymorphonuclear cells and macrophages act to limit local tissue damage caused by inflammatory responses, including signaling cessation of polymorphonuclear cell infiltration, macrophage switching to an anti-inflammatory phenotype, apoptotic cell clearance, and reducing pain caused by nociceptor sensitization (49, 61)