glutathione dehydrogenase Schematic diagram of glutamate catalysis. Under high Glutamate dehydrogenase (GDH), glutamine synthetase

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doi: 10.3389/fphar.2025.1737199 Received 01 November 2025 Revised 21 December 2025 Accepted 29 December 2025 Published 15 January 2026 Volume 16 - 2025 Edited by Dawei Chen, University of Kiel, Germany Reviewed by Eveljn Scarian, University of Pavia, Italy Hong Cheng, Yangzhou University, China Updates Copyright 2026 Knudsen, Tadje, Coggins and Venketaraman

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Thus, the E,Z and E,E isomers are more soluble and can be excreted without conjugation ( 195 , 196 , 197 ), and this is the basis for using phototherapy to prevent neurotoxicity in newborns with hyperbilirubinemia ( 195 , 196 )