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Key highlights from the article: Bottlenecks across the entire value chain: peptide APIs, sterile fill-finish, injector devices, and specialised glass cartridges

Atmane, N., Dairou, J., Paul, A., Dupret, J

Whereas the levels of 1,2-benzoquinone, 11-dehydro-thromboxane B2, 12-KETE, L-malic acid, N2-succinyl-L-ornithine, ornithine, argininosuccinic acid from the fecal metabolites gradually decreased as CKD progressed, chlorohydroquinone, hydroquinone, L-cystine, fecal 12-keto-tetrahydro-leukotriene B4 (12-keto-tetrahydro-LTB4), and L-cysteine levels gradually increased Integrated network analysis based on metabolomics and metagenomics data revealed that Ruminococcus bromii , fecal hydroquinone, and serum creatinine were the major contributors to this network, therefore play major roles in CKD progression

R.PfefferL

All brain areas investigated had decreased levels of ATP5A1 (complex V), ATP5G3 (complex V), and NDUFA5 (complex I) [83, 84]