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This recognizes NAION as a distinct category of GLP-1 injury
It was only in the late 2000s that a biotech called Karuna Therapeutics came onto the scene to combine xanomeline with a muscarinic blocker to minimize side effects, yielding the drug that would eventually become Cobenfy
While clinical evidence 52,53 has indicated a possible elevated risk, causality has not been established
Dose-related effects on the rat fetus (structural abnormalities and reduced body weight) occurred only at higher dosages, equal to or greater than 150 mg/kg (more than 2344-times the 10 mg clinical dose, based on AUC), which were associated with maternal toxicity
So, its important to follow your prescribers guidance and never adjust doses on your own
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