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Esta estimulacin de la secrecin de insulina por GLP-1 en la clula beta en humanos resulta de la capacidad de las incretinas en inhibir la actividad del canal de potasio ATP dependiente en presencia de glucosa, y aumento de influjo de calcio a travs de canales de calcio tipo L voltaje dependiente con aumento del calcio citoslico desde los depsitos intracelulares (14)

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