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Paradoxically, liver-specific FASN knockout promoted hepatic steatosis in mice on a zero-fat diet [60], in which steatosis developed alongside defective PPAR signaling and with a phenotype that could be corrected by dietary fat or a PPAR agonist [60]
Cells in the logarithmic growth phase were harvested from culture flasks and adjusted to a density of 6.0 10 3 cells/well in 96-well plates (100 L/well), followed by incubation at 37 for 24 h
Prijsklasse: 44.95 tot 56.85 LET OP: L-Carnitine wordt kant en klaar geleverd, deze hoeft niet gemengd te worden
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Oxidation of cysteine residues can result in a wide range of redox-based, post-translational modifications, including S-nitrosylation, S-glutathionylation and sulfinic acid, sulfenic acid and disulfide formation 22,23 , which can generate conformational changes in protein structure and subsequent modulation of protein activity 24
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