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For all their promise, GLP-1 and dual GIP/GLP-1 receptor agonists have raised more questions, particularly regarding their long-term safety implications

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Furthermore, Huang-Lian-Jie-Du decoction (HLJDD) medicated serum significantly reduces IL-1 secretion and NLRP3 inflammasome activity through Atg7-mediated autophagy, demonstrating protective effects on the BV2 microglial cell line (Tian et al., 2024)

One peptide with reduced internalization and improved insulinotropism, exendin-phe1, and one with opposing characteristics, exendin-asp3, were selected for further studies (Fig