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[93] Europe [edit] Following discussions on the safety of certain pharmaceutical products derived from kava and sold in Germany, the EU imposed a temporary ban on imports of kava-based pharmaceutical products in 2002

Acs Chem

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After absorption, the substance undergoes conjugation by liver enzymes such as UDP-glucuronosyltransferases (UGTs) and sulphotransferases (SULTs), forming inactive metabolites that further reduce its plasma concentration and limit its distribution to target tissues [53]