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Of relevance, recent evidence indicates that SAM exerts anti-inflammatory effects by reducing the expression of the proinflammatory cytokine tumor necrosis factor-alpha (TNF) and increasing the expression of the anti-inflammatory cytokine interleukin 10 (IL-10)

10.1002/jor.20089 [DOI] [PubMed] [Google Scholar] Staresinic M., Sebecic B., Jadrijevic S., Suknaic S., Perovic D., Aralica G., et al

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The variation reflects different research goals and individual responses