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Assuming a standard deviation (SD) of treatment difference of 0.444 in the log-scale in AUC 024 (according to a preliminary analysis of the food-effect data in study A), a sample size of 24 participants was expected to provide approximately 80% coverage probability to get a 90% confidence interval (CI) for the ratio R of the geometric mean AUC 024 between treatments within [0.841 R , 1.189 R ]

10.1016/j.jnutbio.2009.08.001 65 GemmaM.SheelaO.MontserratV.CintaB.MayteB.JuanF.-L.et al (2010b)

Genetic factors: Certain genetic polymorphisms can result in reduced DAO production or activity

1,25-Dihydroxyvitamin D3 activates MMP13 gene expression in chondrocytes through p38 MARK pathway