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Note: these are averages, suggesting that some patients did not lose as much weight, whilst others exceeded these numbers

3 Introduction/background: a novel dual incretin analog Despite historical research stating GIP did not assist in lowering blood glucose even with supratherapeutic levels, the success of GLP-1 RAs has led to the approval of a novel GLP-1/GIP RA, tirzepatide [42]

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These findings suggest that the GCGR agonism of Retatrutide contributes to the reduction in circulating ANGPTL3/8, which in turn may lead to lower triglyceride and LDL-cholesterol levels

Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: a Bayesian network meta-analysis