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Because comprehensive long term safety data is limited, researchers approach experimentation cautiously and document all observed biological responses

In the multiple-dose trial, semaglutide exposure showed dose proportionality with 40 mg being twofold higher than 20 mg of oral semaglutide in healthy males, without any differences between healthy males compared to T2D male subjects

doi: 10.1038/nm.2002 154 DornelesGPda SilvaIBoeiraMCValentiniDFonsecaSGDal LagoPet al