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Frequency depends on the clinical reason for treatment

2 ) (Genazzani et al., 2011)

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5.4 Combination of systemic therapy and immunotherapy in HCC Before ICI immunotherapy had modified the management of HCC in the past few years, around 50% of patients with HCC received systemic therapies, generally, sorafenib or lenvatinib in the first line, followed by regorafenib, cabozantinib or ramucirumab as the second