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Additionally, we performed quantitative amino acid profiling of individuals from konzo-prone regions which suggests a deficiency in cystine, the precursor for the antioxidant glutathione, which is required by GPx3 to effectively remove ROS from circulation 22

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Moreover, in preclinical studies, semaglutide treatment was associated with an increased abundance of several gut microbial taxa, including Bacteroides, Muribaculaceae, Alloprevotella, Alistipes, Blautia, Dubosiella, Enterococcus, Allobaculum, Clostridia_UCG-014, Coriobacteriaceae_UCG-002 , and notably Akkermansia , suggesting a shift toward a microbiota profile enriched in taxa linked to metabolic regulation (31, 4951)