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Metformin is the most commonly used insulin-sensitizing drug to treat PCOS thanks to its ability to increase insulin sensitivity, reduce hepatic gluconeogenesis, as well as to inhibit hepatic uptake of lactate and alanine, and to increase the conversion of pyruvate to alanine

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This article covers the specific biological mechanisms that create uncertainty, the animal model findings that drive current washout recommendations, and the research design protocols labs use when pregnancy becomes a variable in peptide studies

Andravizou A, Dardiotis E, Artemiadis A, Sokratous M, Siokas V, Tsouris Z, et al