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In India, where many diabetic patients are elderly and managing multiple conditions, this makes gliptins a very practical choice. Mohammad Junaid Rain, MBBS 2nd Year Key advantages of DPP-4 inhibitors: No hypoglycemia risk No weight gain weight neutral Once daily tablet simple to take Safe for elderly patients Can be used with kidney disease (dose adjustment needed) Limitations: Moderate glucose lowering not the strongest drug More expensive than sulfonylureas Rare risk of joint pain and pancreatitis Part 2 Sulfonylureas Common names: Glimepiride, Glipizide, Gliclazide, Glibenclamide Indian brands: Amaryl, Glynase, Diamicron, Daonil Sulfonylureas are the oldest class of oral diabetes drugs used since the 1950s

Dehydration and acute kidney injury (AKI): Severe gastrointestinal side effects can lead to significant fluid loss

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Published online May 23, 2025