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Rapid Initial Loss (First Few Weeks) In the first two to four weeks, most people experience quick weight loss

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As part of the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) program, the efficacy of once-weekly subcutaneous semaglutide was evaluated in over 7,000 patients in six global phase IIIa trials (SUSTAIN 16) across the wide spectrum of the T2D disease course ( Table 1 )

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Updated Phase 3 data from December 2025 (TRIUMPH-4 trial) pushed those numbers even higher, with the 12mg dose delivering 28.7% weight loss at 68 weeks, which works out to approximately 71 lb lost on average