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Several other trials are assessing the safety and efficacy of tirzepatide in improving different cardiometabolic complications such as OSA, MASH and heart failure with preserved ejection fraction (HFpEF) (NCT05412004, NCT04166773, NCT 04847557) [16]

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Although our results are promising with regard to the maintenance of disc height and biomechanical properties in early stages of disease, further long-term in vivo studies will be required to assess clinical translation, particularly in the aspects of reducing low back pain associated with chronic IDD