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Retrieved March 10, 2026, from 18 Khan, S.S., Ndumele, C.E., & Kazi, D.S

They may also have specific requirements when it comes to timing

Timing: Administer 45-60 minutes before desired effect onset

In animal models, this alcohol-induced reward is characterized by activation of the mesolimbic dopamine system, and it can be studied in preclinical models that involve hyperlocomotion, dopamine release in the NAc, and reward in the conditioned place preference (CPP) paradigm (Sanchis-Segura and Spanagel, 2006)