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Experimental investigations have demonstrated that cholangiocytes are sensitive to GLP-1 and respond with augmented proliferation, potentially increasing the risk of duct obstruction [47,48]

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For type 2 diabetes, NICE guidance (NG28) recommends GLP-1 RAs based on individual factors including comorbidities, prior treatments, and HbA1c targets

Injection site reactions , if present, typically resolve within days of the last injection

All the volunteers were also asked to walk for 30 minutes three days a week and to follow a calorie-controlled diet