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For instance, identification of suicidal outcomes by means of ICD codes registered during routine clinical practice databases has been associated with a slight under-registration of cases, which may result in underestimation of the association between drug exposure and SIS outcomes [35], and studies validating suicidal classification have concluded that ICD codes have good positive predictive value but low specificity [36]

Acknowledgements We acknowledge the use of cryo-EM facilities at the Advanced Center for Electron Microscopy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

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