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The compound's effects on insulin sensitivity and triglyceride levels were specifically noted in clinical commentary, with researchers emphasizing that the aim of weight-loss therapy extends beyond weight reduction to include reduction in risk of type 2 diabetes, metabolic syndrome, and cardiovascular diseasegoals that tesofensine appears to address through its documented improvements in insulin sensitivity and triglyceride levels

Additionally, Keap1 mutations are commonly found in NSCLCs such as LUAD and lung squamous carcinoma, and are strongly linked to poor prognosis and resistance to current treatments [55, 56, 93]

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GIP: Fat Metabolism and Insulin Secretion Alongside GLP-1, Mounjaro also activates GIP (Gastric Inhibitory Polypeptide)