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The treatment algorithm was developed as an alternative to the traditional three-tier concept to support personalised treatment tailored to individual patients according to invasiveness, tolerability and effectiveness of the different therapeutic options and patients expectations
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One of its benefits is that it helps improve performance and also encourages recovery
3) Ammonium reduces miR-27b-3p expression, enhancing apoptosis-related gene expression (e.g., TRADD, FADD), thus promoting both death receptor and mitochondrial pathway activation (112, 149)
SS31 (elamipretide) is a mitochondriatargeted tetrapeptide that selectively binds cardiolipin in the inner mitochondrial membrane [1] , stabilizing electron transport chain complexes and reducing reactive oxygen species production while enhancing ATP synthesis [2]
