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Primary neurons were isolated from embryonic WT mice and APP23 AD mice (E17) then treated with exendin-4 with or without compound C, an AMPK inhibitor

Common gastrointestinal side effects reported with the 17.2 mg dose included nausea (35%), diarrhea (25%), constipation (24%), vomiting (24%), abdominal pain (14%), and dyspepsia (13%)

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BPC-157 is studied for potential effects on muscles, tendons, and the gastrointestinal system through mechanisms related to tissue repair, blood flow, and inflammation regulation, with evidence primarily from preclinical research