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This hypothesis was applied to vitamin K [40,41], with proteins required for short-term survival like blood clotting served first, and selenium, with selenoproteins [42]

J Immunol 178(6):36123619 Dejeans N, Pluquet O, Lhomond S, Grise F, Bouchecareilh M, Juin A et al (2012) Autocrine control of glioma cells adhesion and migration through IRE1alpha-mediated cleavage of SPARC mRNA

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The reaction catalyzed by carbamoyl phosphate synthetase I is the regulatory enzyme of the pathway