This typically requires BMI of 30 or higher (or 27 with comorbidities), absence of contraindications, willingness to attend regular study visits, and acceptance of randomization (you might receive placebo)
Tirzepatide has been shown to support greater average weight loss than placebo, with some participants losing a significant amount of their starting weight
It adds psychiatric comorbidities, eating disorder history, and family dynamics as warranting assessment, and says adolescents under active psychiatric care should have input from their mental health provider before anything starts
Moreover, the consumption of palatable food increases extracellular dopamine levels in the nucleus accumbens to regulate food-seeking behaviour 6,7
[See Warnings and Precautions and Use in Specific Populations.] Before initiation of therapy with Janumet and at least annually thereafter, renal function should be assessed and verified as normal