whereas mutations in LRRK2 are associated with idiopathic PD, typically occurring later in life (Nichols et al
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Moreover, following ACMG guidelines (Richards et al., 2015) a large proportion of variants can be classified as of uncertain significance (VUS) or benign, without considering their additive burden in shaping polygenic phenotypes
This shows that while cytosolic Ca 2+ levels in Tgn-treated cells may be partially rebalanced, Ms4a15 OE cells are refractory to uptake