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Unlike nausea, which tends to fade as your body adapts, constipation can continue throughout treatment because the underlying mechanism, delayed gastric and intestinal motility, does not diminish with time

NS4B is a 261 aa membrane protein having four transmembrane domains and helps in membrane association for replication complex3132, inhibits cellular synthesis3334 and modulates RNA-dependent RNA polymerase (RdRp) activity of NS5B35

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Immunoreactive bands on the membrane were visualized with ECL select (GE Healthcare) and scanned with a LAS-4000mini LuminoImage analyzer (Fuji Film, Tokyo, Japan)