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Several ionic mechanisms such as non-selective cation channel, voltage-dependent potassium channel, and TRPC5 channel may be associated with activation of GLP-1R-induced electrophysiological effects (Figure 1A)

This approach is effective because improving food quality can naturally regulate portion sizes and reduce overeating, particularly in environments where food choices are usually uncontrolled

Many patients in the SURPASS trials achieved HbA1c below 5.7 percent, which is the threshold for normal glycemia

The reward centers reduce the dopamine response to food, making that slice of pizza feel less compelling

Cost and access matter, too