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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

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6 Discussion Recent evidence firmly establishes taste perception as a critical link between sensory biology and metabolic regulation, mediated by a complex neuroendocrine crosstalk within the gut-brain-taste axis

A Glimmer of Hope: Maintain Mitochondrial Homeostasis to Mitigate Alzheimer's Disease

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