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doi:10.1016/S0140-6736(22)02033-5 Coskun T, Urva S, Roell WC, et al

The post describes microdose protocols as using lower starting doses with gradual increases, which may let the gastrointestinal system adapt with fewer acute side effects, but it also notes that this approach extends the time needed to reach a therapeutic effect

As for my bipolar symptoms, I havent noticed much change though Im also on lithium and lamotrigine. M.B.B., Facebook Mood Unchanged While on Mounjaro and Antidepressants On Mounjaro, I dont think the drug is making me feel more down than I already am

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Eli Lilly, which owns the retatrutide patent and is running the clinical trials, was equally direct when the ABC asked for comment