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In a follow-up study, 19 months old mice were treated for 21 days

Heesakker, G

The effect typically appears a few months after starting treatment, peaks early, and can last several months before improving as the body adapts

Cave advises: "Seek help for severe, persistent stomach pain radiating to the back, with nausea/vomiting." Differentiate from common GI side effects (mild nausea in 20-40% users)

10.1016/j.jare.2021.07.001 25 BhatiaV.SharmaS