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It is all the more surprising that, although the link between diabetes and cognitive dysfunction was discovered more than 100 years ago and has imperative clinical significance, this complication of diabetes remains relatively poorly understood [28]

Therefore, it is essential to explore an agent that could effectively regulate AQP4

Standard-dose protocols generally follow the same overall concept used in FDA-approved GLP-1 treatment: start low, increase gradually, and adjust based on response and side effects

doi: 10.1179/135100009X392539 294 WilliamsB

The tpst-1 mutant has been shown to exhibit a dwarf phenotype with abnormally root apical meristem, small and pale leaves, and early senescence ( tpst (s) phenotype