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After intraperitoneal injection, gastric emptying was significantly increased in rats given EX-1314 at 5-, 10- and 20-min time points, whereas oral gavage of GHSR agonist produced a significant difference only at the 5-min time point

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Gastrointestinal adverse effects were more commonly reported in the GLP-1 receptor agonist groups, while genital mycotic infections and volume depletion-related adverse effects were more frequently observed in the SGLT2 inhibitor groups