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Oxidative stress and defects in metabolic pathways can promote dysregulation of immune responses in vitiligo [5]

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In vitro assay designs that isolate GLP-1R and GIPR signalling from GCGR signalling for example, using receptor-selective antagonists are one methodological approach used to attribute observed effects to each receptor arm

The collapse of lysosomal homeostasis is reportedly critical for the pathogenesis and development of various diseases, such as tumors, neurodegenerative diseases, cardiovascular diseases, and inflammatory diseases

A significant reduction in appetite and food intake was also observed with tirzepatide compared to placebo in people with T2D [45]