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Within this pathway, diacylglycerol acyltransferase 1/2 (DGAT1/2) catalyzes the esterification of diacylglycerol (DAG) with acyl-CoA, which constitutes the final and rate-limiting step in neutral lipid core formation [215, 216]

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Saxenda is administered as a once-daily subcutaneous injection, with doses gradually increased over several weeks to minimise gastrointestinal side effects