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In contrast to the lack of brain entry of dopamine in vivo [68], our results with the targeted dopamine-nanoformulation using the BBB model combined with midbrain organoids indicate that the nanoformulation may help dopamine to reach the brain tissue after BBB penetration

If side effects show up, we can slow down your titration schedule or give you tips to stay hydrated and eat in a way that supports your comfort

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Exclusion criteria included medical conditions that could confound neurodevelopmental or metabolic assessments (e.g., severe anaemia, vitamin D deficiency, or hyperhomocystinuria)

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