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Response: We thank the commenter for their suggested edit
In addition, IGL-1+MEL was also shown to reduce vascular resistance probably by a mechanism of e-NOS activation leading to increased of nitric oxide concentration, and to have anti-oxidative and anti-inflammatory effects associated with inhibition of the release of pro-inflammatory cytokines, especially TNF and adiponectin (249)
doi: 10.1038/s41467-022-32368-z 28 XuYLuZLingYHouRTaoJDengGet al
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