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The higher labeled glucose derived from [ 13 C 3 ]propionate in fasting mice suggests an increased carbon flux from propionyl-CoA to glucose production, even in the absence of changes in PCC activity

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A subgroup analysis of subject treated with levodopa at baseline (approximately 75% of subjects in the trial) did show significantly longer delays to pre-defined motor worsening in prasinezumab vs placebo-treated subjects (64.4 vs 48.6 weeks