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Quality of evidence: II-B, Strength of recommendation: 1 Panel level of agreement: In total agreement 87%, in partial agreement 8.7%, in partial disagreement 4.3 % Cerebral edema in the patients with ALF causes an increase in intracranial pressure (ICP)

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However, in SUN-treated rats, the daily water consumption was significantly decreased by 28% and 52% in day 14 and day 28, respectively, as compared to day 1 of the treatment protocol

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