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(5.4) (5) Unmasking of Polycythemia Vera:Vitamin B12 deficiency may suppress the signs of polycythemia vera

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In fact, beneficial effects of pycnogenol have been showing all over the biological system on both animals and human studies

[1] [8] Key interactions to be aware of include: Insulin and insulin secretagogues (such as sulphonylureas): Concurrent use may increase the risk of hypoglycaemia, and dose adjustments may be necessary