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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

10.1165/ajrcmb.20.3.3393 67 FlenleyD

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12 mg subcutaneous daily , or 1 mg three times weekly , is the most commonly used GHK-Cu skin dose in published research and clinic practice