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Further, domain specific mutation effects of GNE were observed on mitochondrial dependent cell apoptosis 16

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The medication may also affect hydration status, particularly if gastrointestinal side effects lead to reduced fluid intake or increased losses

L-carnitine co-incubation fully rescued colistin-induced damage in isolated mitochondria as well as in primary cultured tubular cells, whereas the protection in vivo was only partial

I know this book grew out of your experience working with patients, and you sort of started to identify these phenotypes