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doi: 10.1038/s41593-020-00764-7 71 LiJ

mTORC1 as the main gateway to autophagy

Retatrutide may achieve superior weight loss compared to tirzepatide by influencing both calorie intake and calorie burning

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(2023), who noted its ability to suppress inflammation, OS, and tubular cell apoptosis while promoting autophagy flux through a shift towards the intrarenal ACE2/Ang1-7 axis and away from the intrarenal ACE/Ang II axis